Helene Barbour
Assc Professor
Weissman School of Arts and Sciences
Department: Natural Sciences
Areas of expertise:
Email Address: helene.eisenman@baruch.cuny.edu
> View CV- Biography
- Teaching
- Research and Creative Activity
- Grants
- Honors and Awards
- Service
I was born and raised in New York City but decided to travel away from home for my education. I received my B.A. in Biology from Grinnell College in Iowa. As a college student I was first exposed to laboratory research and found that I enjoyed the hands-on aspect of doing science. I decided to continue my science education and went to the University of Wisconsin-Madison for graduate school, where I earned a PhD in Cellular and Molecular Biology. There I did research on the molecular biology of Saccharomyces cerevisiae, or baker’s yeast. Upon returning from the Midwest, I spent several years as a Research Fellow at Albert Einstein College of Medicine in the Bronx. At Einstein I began to study the biology of melanized fungi, the subject of my current research.
My research interests focus on fundamental questions in the biology of melanotic fungi. Melanins are a family of related compounds that have remarkable physical properties. They are found throughout the natural world and have diverse functions ranging from camouflage and display, to protection from ultraviolet radiation, and enhancement of virulence in microbes. Melanins are found in many fungi, including known pathogens, and play important roles in both pathogenesis and environmental survival. I study melanization in Cryptococcus neoformans, a fungal pathogen that is a relatively frequent cause of disease in immunocompromised individuals.
Education
Ph.D., Cellular and Molecular Biology, University of Wisconsin-Madison Madison WI
B.A., Biology, Grinnell College Grinnell Iowa
Semester | Course Prefix | Course Number | Course Name |
---|---|---|---|
Spring 2024 | BIO | 1016 | Fundamentals of Biology |
Spring 2024 | BIO | 1016 | Fundamentals of Biology |
Spring 2024 | BIO | 5000 | Independent Study Biology I |
Fall 2023 | BIO | 4004 | Microbiology |
Fall 2023 | BIO | 4004 | Microbiology |
Spring 2023 | BIO | 4004 | Microbiology |
Spring 2023 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2023 | BIO | 4004 | Microbiology |
Spring 2023 | BIO | 5000 | Independent Study Biology I |
Fall 2022 | BIO | 4004 | Microbiology |
Fall 2022 | BIO | 4004 | Microbiology |
Fall 2022 | IDC | 3002H | Hon Science Forward |
Spring 2022 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2022 | BIO | 1016 | Fundamentals of Biology |
Spring 2022 | BIO | 1016 | Fundamentals of Biology |
Spring 2022 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Fall 2021 | BIO | 4004 | Microbiology |
Fall 2021 | BIO | 4004 | Microbiology |
Spring 2020 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2020 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2020 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2020 | BIO | 1016 | Fundamentals of Biology |
Fall 2019 | IDC | 3002H | Hon Sci & Tech NYC |
Fall 2019 | BIO | 4004 | Microbiology |
Fall 2019 | BIO | 4004 | Microbiology |
Spring 2019 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2019 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2019 | BIO | 1016 | Fundamentals of Biology |
Fall 2018 | BIO | 4004 | Microbiology |
Fall 2018 | BIO | 4004 | Microbiology |
Fall 2018 | IDC | 3002H | Hon Sci & Tech NYC |
Spring 2018 | BIO | 3001 | Principles of Biology II |
Fall 2017 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Fall 2017 | BIO | 4004 | Microbiology |
Spring 2017 | BIO | 3001 | Principles of Biology II |
Fall 2016 | BIO | 1003 | Survey of the Living World |
Fall 2016 | BIO | 4004 | Microbiology |
Spring 2016 | BIO | 1016 | Fundamentals of Biology |
Spring 2016 | BIO | 1016 | Fundamentals of Biology |
Spring 2016 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2016 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2015 | BIO | 1003 | Survey of the Living World |
Spring 2015 | BIO | 1003 | Survey of the Living World |
Spring 2015 | BIO | 5000 | Independent Study Biology I |
Spring 2015 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2015 | BIO | 1016 | Fundamentals of Biology |
Fall 2014 | BIO | 4004 | Microbiology |
Fall 2014 | BIO | 1016 | Fundamentals of Biology |
Fall 2014 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Fall 2014 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2014 | BIO | 1016 | Fundamentals of Biology |
Spring 2014 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Spring 2014 | BIO | 1003L | Survey of the Living World Lec |
Spring 2014 | BIO | 1016 | Fundamentals of Biology |
Fall 2013 | BIO | 1015L | Fund Of Bio - Gen, Evol, & Eco |
Fall 2013 | BIO | 4004 | Microbiology |
Fall 2013 | BIO | 1016 | Fundamentals of Biology |
Fall 2013 | BIO | 1016 | Fundamentals of Biology |
Spring 2013 | BIO | 1003L | Survey of the Living World Lec |
Spring 2013 | BIO | 1003 | Survey of the Living World |
Spring 2013 | BIO | 1003 | Survey of the Living World |
Fall 2012 | BIO | 1003L | Survey of the Living World Lec |
Fall 2012 | BIO | 4004 | Microbiology |
Spring 2012 | BIO | 1003L | Survey of the Living World Lec |
Spring 2012 | BIO | 5000 | Independent Study Biology I |
Spring 2012 | BIO | 1003 | Survey of the Living World |
Fall 2011 | BIO | 1003 | Survey of the Living World |
Fall 2011 | BIO | 4004 | Microbiology |
Spring 2011 | BIO | 5000 | Independent Study Biology I |
Spring 2011 | BIO | 1003L | Survey of the Living World Lec |
Spring 2011 | BIO | 1003 | Survey of the Living World |
Fall 2010 | BIO | 4004 | Microbiology |
Fall 2010 | BIO | 1003 | Survey of the Living World |
Summer 2010 | BIO | 5000 | Independent Study Biology I |
Spring 2010 | BIO | 1003 | Survey of the Living World |
Spring 2010 | BIO | 6002H | Honors Biology II |
Spring 2010 | BIO | 1003L | Survey of the Living World Lec |
Fall 2009 | BIO | 6001H | Biology Honors I |
Fall 2009 | BIO | 1003L | Survey of the Living World Lec |
Fall 2009 | BIO | 4004 | Microbiology |
Spring 2009 | BIO | 1003 | Survey of the Living World |
Spring 2009 | BIO | 1003 | Survey of the Living World |
Spring 2009 | BIO | 1003L | Survey of the Living World Lec |
Fall 2008 | BIO | 4004 | Microbiology |
Journal Articles
Eisenman, H. C., Greer, E. M., & McGrail, C. W. (2020). The role of melanins in melanotic fungi for pathogenesis and environmental survival. Applied Biotechnology and Microbiology,
Eisenman, H. C. (2015). Metamorphosis of Galleria mellonella research. 6. 1-2 (Invited Editorial).
Eisenman, H. C., Duong, R., Chan, H., Tsue, R., & McClelland, E. (2014). Reduced virulence of melanized Cryptococcus neoformans in Galleria mellonella. Virulence, 5. 611-618 (Featured on the journal cover).
Eisenman, H. C., & Casadevall, A. (2012). Synthesis and Assembly of Fungal Melanin. Applied Microbiology and Biotechnology, 93. 931-40.
Eisenman, H. C., Chow, S., Tse, K., McClelland, E., & Casadevall, A. (2011). The effect of L-DOPA on Cryptococcus neoformans growth and gene expression. Virulence, 2. 329-36.
Eisenman, H. C., Frases-Carvajal, S., Rodrigues, M., Nicola, A., & Casadevall, A. (2009). Vesicle-associated melanization in Cryptococcus neoformans. Microbiology, 155. 3860-7.
Eisenman, H. C., Mues, M., Weber, S. E., Chaskes, S., Gerfen, G., & Casadevall, A. (2007). Cryptococcus neoformans laccase catalyzes melanin synthesis from both D- and L-DOPA. Microbiology , 153. 3954-3962.
Eisenman, H. C., Casadevall, A., & McClelland, E. E. (2007). New Insights on the Pathogenesis of Invasive Cryptococcus neoformans infection. Current Infectious Disease Reports , 9(457-464).
Garcia-Rivera, J., Eisenman, H. C., Nosanchuk, J. D., Aisen, P., Zaragoza, O., Moadel, T., Dadachova, E., & Casadevall, A. (2005). Comparative analysis of Cryptococcus neoformans acid resistant particles generated from pigmented cells grown in different laccase substrates. Fungal Genetics and Biology , 42. 989-998 (Featured on the journal cover).
Eisenman, H. C., Nosanchuk, J., Webber, J., Emerson, R., Camesano, T., & Casadevall, A. (2005). The microstructure of cell wall-associated melanin in the pathogenic fungus Cryptococcus neoformans. Biochemistry, 44. 3683-93.
Eisenman, H. C., & Craig, E. A. (2004). Activation of pleiotropic drug resistance by the J-protein and Hsp70-related proteins, Zuol and Sszl. Molecular Microbiology , 53. 335-344.
(2003). Ribosome-tethered molecular chaperones: the first line of defense against protein misfolding?. Current Opinion in Microbiology , 6. 1-6.
Hundley, H., Eisenman, H. C., Walter, W., Evans, T., Hotokezaka, Y., Wiedmann, M., & Craig, E. (2002). The in vivo function of the ribosome-associated Hsp70, Sszl, does not require its putative peptide-binding domain. Proceedings of the National Academy of Sciences, USA, 99(4203-4208).
(1997). Activation at a distance: involvement of nucleoprotein complexes that remodel chromatin. Gene Therapy and Molecular Biology, 1. 483-494.
Book Chapters
Eisenman, H. C. (2024). "A Galleria Model of Cryptococcus neoformans Infection". In McClelland, E. (Ed.), Cryptococcus neoformans: Methods and Protocols New York, NY. Humana.
McClelland, E., Casadevall, A., & Eisenman, H. C. (2007). Pathogenesis of Cryptococcus neoformans. In Kavanagh, K. (Ed.), (pp. 131-158). Springer, Dordrecht,The Netherlands. New Insights in Medical Mycology.
Presentations
Barbour, H. Come to the dark side...we have melanin. Beyond the Fold, Celebrating the career of Betty Craig. University of Wisconsin-Madison
Barbour, H. From yeast to mushrooms, a biology journey. Brooklyn Technical High School Microbiology Club. Brooklyn: Brooklyn Technical High School Microbiology Club.
Tabassum, T., Dong, F., Wauchope, O. R., & Eisenman-Barbour, H. C. (2019, October 26). Chemical Analysis of Melanin Inhibition of Cryptococcus neoformans. MACUB 52nd Annual Fall Conference. Monmouth University, New Jersey: Metropolitan Association of College and University Biologists.
Eisenman, H. C., Dong, F., & Tabassum, T. (2019, June 29). Investigating Cryptococcus neoformans melanin production in the presence of redox reagents. NorthEastern Microbiologists: Physiology, Ecology and Taxonomy Meeting 2019. Minnowbrook Lodge, Blue Mountain Lake, NY: NorthEastern Microbiologists: Physiology, Ecology and Taxonomy.
Eisenman, H. C. (2015, April 9). Walking on the dark side - synthesis and function of fungal melanin. Middle Tennessee State University. Murfreesboro, TN: Molecular Biosciences and Biology Program.
Eisenman, H. C., Duong, R., & Tsue, R. E. (2013, May 20). Melanized Cryptococcus neoformans elicits nodule formation in Galleria mellonella. 113th General Meeting of the American Society for Microbiology. Denver, CO
Eisenman, H. C., & Chan, H. (2010, May 31). Virulence of Melanized Cryptococcus neoformans in the Waxmoth Caterpillar, Galleria Mellonella. 110th General Meeting of the American Society for Microbiology. San Diego, CA
Eisenman, H. C. (2008, May 31). Mechanisms of the Protective Role of Melanin. 108th General Meeting of the American Society for Microbiology. Boston, MA: American Society for Microbiology.
Eisenman, H. C., & Casadevall, A. (2007, May 31). Cryptococcus neoformans Genes Induced in the Presence of Melanization Substrate. 107th General Meeting of the American Society for Microbiology. Toronto, Ontario, Canada
Eisenman, H. C. (2006, December 31). Cell Wall Melanin in Cryptococcus neoformans. The 16th Congress of the International Society of Human Animal and Mycology. Paris, France
Eisenman, H. C., & Casadevall, A. (2005, May 31). Mutants in Cryptococcus neorformans with increased susceptibility to melanization substrate. 105th General Meeting of the American Society for Microbiology. Atlanta, Georgia
Eisenman, H. C., Nosanchuk, J. D., Webber, J. B., Emerson, R. J., Camesano, T. A., & Casadevall, A. (2004, December 31). The microstructure of melanin in Cryptococcus neoformans. 5th Louis Pasteur Conference on Infectious Diseases. Paris, France
Eisenman, H. C., Hundley, H., & Craig, E. (2002, May 31). Distinct roles of the ribosome-associated Hsp70 Sszl in protein synthesis and pleiotropic drug resistance. American Society of Cell Biology 42nd Annual Meeting. San Francisco, California
Bresnick, E. H., Tze, L., Eisenman, H. C., Forsberg, E. C., Lam, L. T., & Versaw, W. K. (1997, December 31). Distance-dependent and-independent mechanisms of transcriptional activation by the human beta-globin locus control region. Red Cell Gordon Conference. Tilton, New Hampshire
Other Scholarly Works
Friedman, J. M., Friedman, A. J., Han, G., Navati, M. S., Davies, K. P., Tar, M. T., Alfieri, A. A., Casadevall, A., Dadachova, E., Eisenman, H. C., N/A, J., & Spray, D. (2011). Versatile Nanoparticulate Biomaterial for Controlled Delivery and/or Containment of Therapeutic and Diagnostic Material.
Research Currently in Progess
Eisenman, H. C., & Wauchope, O.(n.d.). Effect of Oxidizing Agents on Melanization of Cryptococcus neoformans. In Progress.
Title | Funding Agency Sponsor | Start Date | End Date | Awarded Date | Total Funding | Status |
---|---|---|---|---|---|---|
Microbiological and biochemical analysis of fungal melanin inhibition | PSC-CUNY 51 | 07/01/2020 | 12/31/2022 | 04/17/2020 | 3500 | Completed |
Lipid Metabolism and Fungal Melanization | PSC-CUNY 49 | 07/01/2018 | 06/30/2019 | 04/15/2018 | 3500 | Completed |
Oxidative Stress and Melanization of Cryptococcus neoformans | PSC-CUNY 45 | 07/01/2014 | 06/30/2015 | 04/15/2014 | 3500 | Completed |
Cellular Immune Response of Galleria mellonella to Melanized Fungi | PSC-CUNY 44 | 07/01/2013 | 06/30/2014 | 04/15/2013 | 3500 | Completed |
Fungal pathogenesis in an invertebrate host | PSC-CUNY 42 | 07/01/2011 | 06/30/2012 | 04/15/2011 | 3500 | Completed |
Establishing a model for Cryptococcus neoformans melanization studies | PSC-CUNY 41 | 07/01/2010 | 06/30/2011 | 6000 | Completed | |
Characterizing novel genes | PSC-CUNY 40 | 07/01/2009 | 06/30/2010 | 0 | Completed |
Honor / Award | Organization Sponsor | Date Received | Description |
---|---|---|---|
Certificate of Appreciation | Center for Teaching and Learning, Baruch College | 2020-10-16 | Organization and resource sharing with biology instructors during the sudden shift to distance learning in the spring of 2020. |
Fellowship Leave Award | Baruch College, CUNY | 2020-08-27 | |
2nd Annual Faculty Assignment Design Challenge Weissman Faculty Award | MakerHub, Baruch College Lawrence N. Field Center for Entrepreneurship | 2017 | |
NIH Ruth L. Kirschstein National Research Service Award (F32) | 2005 | ||
NIH Immunology and Immunooncology Training Program Fellowship, Albert Einstein College of Medicine | 2004 | ||
Vilas Travel Fellowship | University of Wisconsin-Madison | 2002 | |
NIH Biotechnology Training Program Fellowship | University of Wisconsin-Madison | 1997 | |
Honors in Biology Major | Grinnell College | 1994 | |
Phi Beta Kappa | Grinnell College | 1994 |
College
Committee Name | Position Role | Start Date | End Date |
---|---|---|---|
Baruch College Faculty Senate | Senator | Present | |
WSAS Pod Mentorship Program | Faculty Mentor | Present | |
Tenure and Promotions Guidelines Committee | Committee Member | Present | |
Natural Sciences Department Honors Committee | Committee Chair | Present | |
Deputy Chair of Biology | Deputy Chair of Biology | 8/25/2022 | |
Natural Sciences Department Executive Committee | Committee Member | 7/31/2022 | |
Search Committee, Assistant Professor of Biology | Committee Chair | 7/28/2022 | |
Academic Freedom and Responsibility Committee | Committee Member | 4/22/2022 | |
Authored Department of Natural Sciences Biology Self Study for External Review | Author | 12/31/2018 | |
Search Committee, Assistant Professor of Environmental Studies | Equity Advocate | 12/31/2017 | |
Biomedical Recommendations Committee | Committee Member | 12/31/2017 | |
Baruch College Majors and Minors Fair | Attendee, Meeting | 12/31/2017 | |
Ad Hoc Committee on Faculty Recognition | Committee Member | 12/31/2016 | |
Course Coordinator for BIO 1003 | 12/31/2016 | ||
Course Coordinator for BIO 1015L and BIO 1016 | 12/31/2016 | ||
Search Committee, Asst. Prof. of Molecular/Cellular Biology | Committee Member | 12/31/2015 | |
Representative to School of Public Affairs | 12/31/2013 | ||
Committee on Undergraduate Honors | Committee Member | 12/31/2013 | |
Laboratory Design Committee | Committee Member | 12/31/2010 | |
Alliance for Minority Progress Steering Committee | Committee Member | 12/31/2009 | |
Biology Major Committee | Committee Member | 12/31/2009 | |
Natural Sciences Design Subcommittee | Committee Member | 12/31/2008 |
University
Committee Name | Position Role | Start Date | End Date |
---|---|---|---|
Common Core Course Review Committee | Committee Member | 1/1/2015 | Present |
Creativity in STEM Steering Committee | Committee Member | 1/1/2018 | 12/31/2019 |
Common Core Course Review Committee | Committee Chair | 12/31/2018 | |
Research Committee | Alternate | 1/1/2012 | 12/31/2014 |
Professional
Organization | Position Role | Organization State | Organization Country | Start Date | End Date | Audience |
---|---|---|---|---|---|---|
New York Mycological Society | Member | 1/1/2017 | Present | |||
Virulence | Reviewer, Journal Article | New York | United States | Present | International | |
Pathogems | Editor | none | Switzerland | Present | International | |
Microbial Pathogenesis | Reviewer, Journal Article | New York | United States | Present | International | |
Microbial Pathogenesis | Reviewer, Journal Article | New York | United States | Present | International | |
PLoS Neglected Tropical Diseases | Reviewer, Journal Article | California | United States | Present | International | |
New York Mycological Society | Member | New York | United States | Present | State | |
Environmental Microbiology Reportd | Reviewer, Journal Article | New York | United States | Present | International | |
Microbial Pathogenesis | Reviewer, Journal Article | New York | United States | Present | International | |
Frontiers in Microbiology | Reviewer, Journal Article | New York | United States | Present | International | |
Biologia | Reviewer, Journal Article | New York | United States | Present | International | |
Fungal Biology Reviews | Reviewer, Journal Article | New York | United States | Present | International | |
Frontiers in Microbiology | Reviewer, Journal Article | New York | United States | Present | International | |
New York Mycological Society | Volunteer | New York | United States | 5/2/2022 | Present | Local |
African Journal of Microbiology Research | Reviewer, Journal Article | New York | United States | Present | International | |
Defense Threat Reduction Agency | Grant Proposal Reviewer | DC | United States | Present | National | |
Microbiology | Reviewer, Journal Article | New York | United States | Present | International | |
Virulence | Reviewer, Journal Article | New York | United States | Present | International | |
Biochemistry and Cell Biology | Reviewer, Journal Article | New York | United States | Present | International | |
Mycopathologia | Reviewer, Journal Article | New York | United States | Present | International | |
PLoS One | Reviewer, Journal Article | New York | United States | Present | International | |
American Society for Microbiology | Member | DC | United States | Present | International | |
New York Academy of Sciences | Member | New York | United States | Present | State | |
Frontiers in Fungi and Their Interactions | Review Editor | 1/1/2011 | Present | |||
American Society for Microbiology | Member | 1/1/2004 | Present | |||
Medical Mycological Society of the Americas | Member | 1/1/2008 | Present | |||
New York Academy of Sciences | Member | 1/1/2010 | Present | |||
Microbial Pathogenesis | Reviewer, Journal Article | 12/31/2020 | ||||
Microbial Pathogenesis | Reviewer, Journal Article | 12/31/2019 | ||||
Pathogens | 12/31/2019 | |||||
Environmental Microbiology Reports | Reviewer, Journal Article | 12/31/2018 | ||||
Microbial Pathogenesis | Reviewer, Journal Article | 12/31/2018 | ||||
Frontiers in Microbiology | Reviewer, Journal Article | 12/31/2017 | ||||
Biologia | Reviewer, Journal Article | 1/1/2016 | 12/31/2016 | |||
Fungal Biology Reviews | Reviewer, Journal Article | 1/1/2016 | 12/31/2016 | |||
Virulence | Reviewer, Journal Article | 12/31/2015 | ||||
Frontiers in Microbiology | Reviewer, Journal Article | 12/31/2015 | ||||
Defense Threat Reduction Agency | Reviewer, Grant Proposal | 12/31/2014 | ||||
Microbiology | Reviewer, Journal Article | 12/31/2014 | ||||
Virulence | Reviewer, Journal Article | 12/31/2014 | ||||
African Journal of Microbiology Research | Reviewer, Journal Article | 12/31/2014 | ||||
Biochemistry and Cell Biology | Reviewer, Journal Article | 12/31/2012 | ||||
Mycopathologia | Reviewer, Journal Article | 12/31/2012 | ||||
PLoSONE | Reviewer, Journal Article | 12/31/2009 |
Public
Organization | Position Role | Organization State | Organization Country | Start Date | End Date | Audience |
---|---|---|---|---|---|---|
New York Botanical Garden | Herbarium Volunteer | New York | Virgin Islands | 7/5/2023 | Present | Local |
44th Annual Fall Metropolitan Association of College and University Biologists Conference | Volunteer Judge | New Jersey | 12/31/2011 | |||
43rd Annual Fall Metropolitan Association of College and University Biologists Conference | Volunteer Judge | New York | 12/31/2010 | |||
New York City Science and Engineering Fair Preliminary Event | Volunteer Judge | New York | 12/31/2009 |