Pablo Marco Peixoto

Education

Ph.D., Cell Biophysics, University of Extremadura Spain

MSc, Biochemistry, Federal University of Uberlandia Brazil

BSc, Biological Sciences, Federal University of Uberlandia Brazil

Artistic and Creative Activities

Peixoto, P. M. (2017). Mitochondrial Ion Channels and Transporters. Springer.

Journal Articles

(2023). The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore. 120(51). e2303713120.

Karch, J. M., Bround, M. J., Khalil, H., Sargent, M., Latchman, N., Terada, N., Peixoto, P. M., & Molkentin, J. D. (2019). Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances, 5(8). eaaw4597.

Mirzalieva, O., Jeon, S., Hartke, R., Damri, K., Drwesh, L., Azem, A., Dunn, C., & Peixoto, P. M. (2019). Deletion of Mgr2p affects the gating behavior of the TIM23 complex. Frontiers in Physiology, 15(9). 1960.

Solesio, M. E., Peixoto, P. M., Debure, L., Madamba, S. M., de Leon, M. J., Wisniewski, T., Pavlov, E. V., & Fossati, S. (2018). Carbonic anhydrase inhibition selectively prevents amyloid ß neurovascular mitochondrial toxicity. Aging cell, 17(4). e12787.

Couto-Lima, C., Peixoto, P. M., Machado, M., Molina, R., Trinca, V., Anhezini, L., Mantovani, M., Oliveira, R., Colon, D., Monesi, N., Alberici, L., Ramos, R., & Espreafico, E. M. (2017). EMC1 is required for the sarcoplasmic reticulum and mitochondrial integrity in the Drosophila muscle. Journal of Cell Science, 47pp.

Kawamata, H., Peixoto, P. M., Konrad, C., Palomo, G., Bredvik, K., Gerges, M., Valsecchi, F., Petrucelli, L., Ravits, J. M., Starkov, A., & Manfredi, G. (2017). Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo. Molecular Neurodegeneration, 12(1). 37.

Campo, M. L., Peixoto, P. M., & Martínez-Caballero, S. (2016). Revisiting trends on mitochondrial mega-channels for the import of proteins and nucleic acids. Journal of Bioenergetics and Biomembranes, 49(1). 75-99.

Peixoto, P. M., Teijido, O. H., Mirzalieva, O., Dejean, L. M., Pavlov, E., & Kinnally, K. W. (2016). MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers. Journal of Bioenergetics and Biomembranes, 49(1). 65-74.

Madamba, S., Damri, K., Dejean, L. M., & Peixoto, P. (2015). Mitochondrial Ion Channels in Cancer Transformation. Frontiers in Oncology, 5. 120.

Jackman, K., Zhou, P., Faraco, G., Peixoto, P. M., Coleman, C., Voss, H., Pickel, V., Manfredi, G., & Iadecola, C. (2014). Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury. Stroke, 45(5). 1460-1467.

Izidoro-Toledo, T. C., Borges, A. C., Araujo, D. D., Mazzi, D. P., Nascimento, Junior, F. O., Sousa, J. F., Alves, C. P., Paiva, A. P., Trindade, D. M., Patussi, E. V., Peixoto, P. M., Kinnally, K. W., & Espreafico, E. M. (2013). A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells. Cell Death Dis, 4. e547.

Karch, J., Kwong, J. Q., Burr, A. R., Sargent, M. A., Elrod, J. W., Peixoto, P. M., Martinez-Caballero, S., Osinska, H., Cheng, E. H., Robbins, J., Kinnally, K. W., & Molkentin, J. D. (2013). Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife, 2. e00772.

Peixoto, P. M., Kim, H., Sider, B., Starkov, A., Horvath, T., & Manfredi, G. (2013). UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis. Molecular and Celular Neuroscience, 57. 104-110.

Peixoto, P., Dejean, L. M., & Kinnally, K. W. (2012). The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration. Mitochondrion, 12(1). 14-23.

Calabria, L. K., Peixoto, P. M., Passos Lima, A. B., Peixoto, L. G., de Moraes, V. R., Teixeira, R. R., Dos Santos, C. T., LO, E. S., da Silva Mde, F., dos Santos, A. A., Garcia-Cairasco, N., Martins, A. R., Espreafico, E. M., & Espindola, F. S. (2011). Myosins and DYNLL1/LC8 in the honey bee (Apis mellifera L.) brain. J Insect Physiol, 57(9). 1300-1311.

Peixoto, P. M., Lue, J. K., Ryu, S. Y., Wroble, B. N., Sible, J. C., & Kinnally, K. W. (2011). Mitochondrial apoptosis-induced channel (MAC) function triggers a Bax/Bak-dependent bystander effect. Am J Pathol, 178(1). 48-54.

Kinnally, K. W., Peixoto, P. M., Ryu, S. Y., & Dejean, L. M. (2011). Is mPTP the gatekeeper for necrosis, apoptosis, or both?. Biochim Biophys Acta, 1813(4). 616-622.

Patricio, K., Calabria, L. K., Peixoto, P. M., Espindola, F. S., & Da Cruz-Landim, C. (2010). Characterization and localization of dynein and myosins V and VI in the ovaries of queen bees. Cell Biol Int, 34(10). 1041-1047.

Dejean, L. M., Ryu, S. Y., Martinez-Caballero, S., Teijido, O., Peixoto, P. M., & Kinnally, K. W. (2010). MAC and Bcl-2 family proteins conspire in a deadly plot. Biochim Biophys Acta, 1797(6-7). 1231-1238.

Peixoto, P. M., Ryu, S. Y., & Kinnally, K. W. (2010). Mitochondrial ion channels as therapeutic targets. FEBS Lett, 584(10). 2142-2152.

Ryu, S. Y., Peixoto, P. M., Teijido, O., Dejean, L. M., & Kinnally, K. W. (2010). Role of mitochondrial ion channels in cell death. Biofactors, 36(4). 255-263.

Ryu, S. Y., Peixoto, P. M., Won, J. H., Yule, D. I., & Kinnally, K. W. (2010). Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry. Cell Calcium, 47(1). 65-76.

Peixoto, P. M., Ryu, S. Y., Bombrun, A., Antonsson, B., & Kinnally, K. W. (2009). MAC inhibitors suppress mitochondrial apoptosis. Biochem J, 423(3). 381-387.

Peixoto, P. M., Ryu, S. Y., Pruzansky, D. P., Kuriakose, M., Gilmore, A., & Kinnally, K. W. (2009). Mitochondrial apoptosis is amplified through gap junctions. Biochem Biophys Res Commun, 390(1). 38-43.

Peixoto, P. M., Grana, F., Roy, T. J., Dunn, C. D., Flores, M., Jensen, R. E., & Campo, M. L. (2007). Awaking TIM22, a dynamic ligand-gated channel for protein insertion in the mitochondrial inner membrane. J Biol Chem, 282(26). 18694-18701.

Martinez-Caballero, S., Peixoto, P. M., Kinnally, K. W., & Campo, M. L. (2007). A fluorescence assay for peptide translocation into mitochondria. Anal Biochem, 362(1). 76-82.

Iniesta, V., Carcelen, J., Molano, I., Peixoto, P. M., Redondo, E., Parra, P., Mangas, M., Monroy, I., Campo, M. L., Nieto, C. G., & Corraliza, I. (2005). Arginase I induction during Leishmania major infection mediates the development of disease. Infect Immun, 73(9). 6085-6090.

Nunes, F. M., Valente, V., Sousa, J. F., Cunha, M. A., Pinheiro, D. G., Maia, R. M., Araujo, D. D., Costa, M. C., Martins, W. K., Carvalho, A. F., Monesi, N., Nascimento, A. M., Peixoto, P. M., Silva, M. F., Ramos, R. G., Reis, L. F., Dias-Neto, E., Souza, S. J., Simpson, A. J., Zago, M. A., Soares, A. E., Bitondi, M. M., Espreafico, E. M., Espindola, F. S., Paco-Larson, M. L., Simoes, Z. L., Hartfelder, K., & Silva, Jr., W. A. (2004). The use of Open Reading frame ESTs (ORESTES) for analysis of the honey bee transcriptome. BMC Genomics, 5. 12pp.

Book Chapters

Aung, M. S., Hartke, R., Madamba, S., Mirzalieva, O., & Peixoto, P. M. (2017). Protein Import Channels in the Crossroads of Mitochondrial Function.. In Rostovtseva, T. K. (Ed.), Molecular Basis for Mitochondrial Signaling (pp. 317-347). Springer International Publishing.

Peixoto, P. M., Pavlov, E. E., & Kinnally, K. W. (2015). Mitochondrial Channels in Neurodegeneration. In Gribkoff, V. K., Jonas, E. A., & Hardwick, J. M. (Eds.), The Functions, Disease-Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria (pp. 65-100). Hoboken, NJ,United States. Wiley.

Kinnally, K. W., & Peixoto, P. (2015). Electrophysiology of the Mitochondrial Apoptosis-Induced Channel, MAC.. In Delcour, A. (Ed.), Unconventional Ion Channels and Pores. Springer Series in Biophysics. (pp. 59-74). United States. Springer International Publishing.

Peixoto, P. M., Marinez-Caballero, S., Grigoriev, S., Kinnally, K. W., & Campo, M. L. (2004). The ins and outs of mitochondrial channels from an electrophysiological point of view.. Recent Research Developments in Biophysics (pp. 413-474). Kerala,India. Transworld Research Signpost.

Media Contributions

Peixoto, P. M. (2016). Scientificos y las redes sociales, (1).

(2016). College Talk # 5: The engines that fuel the living cells.

(2016). Comunica UFU - Brazil.

(2016). Destination Weissman.

(2015). Wazo Magazine.

(2015). Wazo Magazine.

(2007). Wikipedia.

Presentations

Peixoto, P. (2021, February 2). Retraction or reshaping: mitochondrial regulation of synaptic plasticity. Center for Computational and Integrative Biology Spring Seminars. Camden, NJ: Rutgers Unviersity.

Zapata, K. M., Aronskyy, I., Madamba, S., & Peixoto, P. M. (2019, February 4). Optogenetic Regulation of Mitochondrial Function and Synaptic Plasticity In Vivo. 63rd Annual Meeting of the Biophysical Society. Baltimore, MD: Biophysical Society.

Zapata, K. M., Aronskyy, I., Madamba, S., & Peixoto, P. M. (2019, February 20). Optogenetic regulation of mitochondrial and neuromuscular function in vivo. Gordon Research Conference: Mitochondrial physiology in health and disease. Ventura, CA: GRC.

Mirzalieva, O., Jeon, S., Dwresh, L., Azem, A., & Peixoto, P. M. (2019, March 4). Loss of Mgr2P Destabilizes the TIM23 Channel and Reduces Mitochondrial Emission of Reactive Oxygen Species. 63rd Annual Meeting of the Biophysical Society. Baltimore, MD: Biophysical Society.

Madamba, S., Rivera, N., Brian, N., & Peixoto, P. M. (2018, February 11). Optogenetic Regulation of Mitochondrial ROS Emission In Vivo. 62nd Annual Meeting of the Biophysical Society. San Francisco, CA: Biophysical Society.

Mirzalieva, O., Dwresh, L., Azem, A., & Peixoto, P. M. (2018, February 10). Mgr2 and the Channel Activity of TIM23, a Gateway for Mitochondrial Protein Import. 62nd Annual Meeting of the Biophysical Society. Brooklyn: Biophysical Society.

Peixoto, P. (2018, May 8). Emerging roles of mitochondrial metabolic waste. 2nd Natural Sciences Department Retreat. CUNY-Advanced Research Science Center

Peixoto, P. (2018, September 7). Stress or signaling: emerging roles of emissions from the cellular power plant. Biology Seminar Series. Queens College Department of Biology: Queens College.

Peixoto, P. M. (2017, February 11). Mitochondrial Redox Regulation in Health and Disease. 61th Annual Meeting of the Biophysical Society. Los Angeles: Biophysical Society.

Damri, K., Hartke, R., Mirzalieva, O., & Peixoto, P. M. (2017, February 14). MGR2 Depletion Affects Protein Import and Mitochondrial Metabolism. 61th Annual Meeting of the Biophysical Society. Los Angeles: Biophysical Society.

Peixoto, P. M. (2016, May 14). Artistic Expressions in Scientific Research. 1st Wazo Day. Almendralejo, Spain: Wazo Magazine.

Aung, M., Madamba, S., & Peixoto, P. M. (2016, February 11). Depletion of BAK Affects Emission of Reactive Oxygen Species from Mitochondria. 60th Annual Meeting of the Biophysical Society. Los Angeles: Biophysical Society.

Peixoto, P. M., Teijido, O., Dejean, L., Pavlov, E., & Kinnally, K. (2015, February 12). MAC Inhibitors Neutralize the Pro-Apoptotic Effects of Tbid. 59th Annual Meeting of the Biophysical Society. Baltimore: Biophysical Society.

Peixoto, P. M. (2015, March 5). The cross roads of mitochondrial apoptosis. Biology Seminar Series. Istambul, Turkey: Koc University.

Peixoto, P. M. (2015, May 11). To kill or not to kill. A mitochondrial dillema.. Spring Biology Seminar. Bronx, NY: Lehman College.

Peixoto, P. M., Mirzaleva, O., & Kinnally, K. (2015, September 25). MAC inhibitors neutralize the pro-apoptotic effects of tBid. Mitochondrial DNA and neurodegeneration. Sitges, Spain: European Molecular Biology Organization.

Peixoto, P. M. (2015, October 25). Faculty Positions in Academia. What Can You Be With a PhD. NYU School of Medicine, New York, NY: NYU School of Medicine, Columbia University College of Physicians and Surgeons, Cornell, Yale, Cold Spring Harbor Laboratory, Albert Einstein College of Medicine, Rutgers Grad School of Biomedical Sciences, The Rockefeller University, CUNY.

Peixoto, P. M., Kim, H., & Manfredi, G. (2014, February 13). . 58th Annual Meeting of the Biophysical Society. San Francisco: Biophysical Society.

Peixoto, P. M., Kim, H., Sider, B. S., Starkov, A., & Manfredi, G. (2013, May 6). UCP2 overexpression decreases mitocohndrial function. NHLBI Mitochondrial Biology Symposium. Bethesda, MD: National Institutes of Heatlh.

Peixoto, P. M., Lue, J. K., Ryu, S., & Kinnally, K. W. (2011, February 28). MAC Function Triggers a Bax/Bak Dependent Bystander Effect. 55th Annual Meeting of The Biophysical Society. Baltimore, MD: Biophysical Society.

Peixoto, P. M. (2011, May 4). MAC Function triggers bystander cell death. NYU FSDC Awards 2011. New York: NYU College of Dentistry.

Peixoto, P. M. (2011, June 21). MAC and tumor cell death. Emily Cheng Seminar Series. New York: Memorial Sloan Kettering Cancer Center.

Peixoto, P. M. (2011, August 5). MAC and the crossroads of cell death. Seminar Series on Mitochondrial Diseases. New York: Weill Cornell Medical College.

Peixoto, P. M. (2011, August 19). MAC function propagates between cells. Research Seminar Series. New York: Columbia University College of Physicians and Surgeons.

Peixoto, P. M. (2010, February 20). To block apoptosis. 54th Annual Meeting of the Biophysical Society. San Francisco: Biophysical Society.

Peixoto, P. M., Renken, C., Haldar, S., Mannella, C., & Kinnally, K. W. (2010, February 28). In Search of the Structure of MAC in the Mitochondrial Outer Membrane. 54th Annual Meeting of The Biophysical Society. San Francisco, CA: Biophysical Society.

Peixoto, P. M. (2010, May 7). Effects of MAC on mitochondrial morphology. Post Doctoral Research Workshop. New York: NYU Langone Medical Center.

Peixoto, P. M. (2010, March 29). Mitochondrial ion channels in cell death. Faculty Seminar Series. Pamplona, Spain: University of Navarra Medical School.

Peixoto, P. M., Ryu, S., Range, R., & Kinnally, K. W. (2010, February 28). Effects of MAC Formation on Mitochondrial Morphology. 54th Annual Meeting of The Biophysical Society. San Francisco, CA: Biophysical Society.

Peixoto, P. M., & Kinnally, K. W. (2010, July 31). MAC induces mitochondrial fragmentation. 6th European Bioenergetics Conference. Warsaw, Poland: Polish Biochemical Society.

Peixoto, P. M., Gonzales-Fernandez, L., Bermejo, P., & Campo, M. (2010, July 31). Molecular dynamics of the mitochondrial protein translocase TIM22: Structure function correlations of the channel's partakers. 6th European Bioenergetics Conference. Warsaw, Poland: Polish Biochemical Society.

Peixoto, P. M. (2010, July 25). MAC, apoptosis and mitochondrial dynamics. 15th Meeting Braz. Soc. for Cell Biol.. Sao Paulo: Brazilian Society for Cell Biology.

Peixoto, P. M. (2010, May 23). MAC and mitochondrial dynamics. NYU FSDC Awards 2010. New York: NYU College of Dentistry.

Ryu, S., Peixoto, P. M., & Kinnally, K. W. (2009, February 28). Extracellular ATP Mediates The Intercellular Ca2+ Wave Induced By Mechanical Stimulation In Human Salivary Gland Cells. 53th Annual Meeting of The Biophysical Society. Boston, MA: Biophysical Society.

Peixoto, P. M., Ryu, S., Antonsson, B., & Kinnally, K. W. (2009, February 28). Apoptosis in FL5.12 cells is suppressed by inhibitors of the Mitochondrial Apoptosis-induced Channel MAC. 53th Annual Meeting of The Biophysical Society. Boston, MA: Biophysical Society.

Campo, M., Peixoto, P. M., Roy, T. J., & Corraliza, I. M. (2009, July 4). The channel of the mitochondrial inner membrane protein translocase TIM22: structure-function correlations and insights into the biogenesis the complex.. 34th FEBS Congress. Prague, Czech Republic: FEBS.

Peixoto, P. M. (2008, February 4). Pharmacology of the cytochrome c release channel, MAC. 52th Annual Meeting of the Biophysical Society. San Diego: Biophysical Society.

Peixoto, P. M., Tyhovich, N., Terracio, L., Antonsson, B., & Kinnally, K. W. (2007, September 26). Blockade of the cytochrome c release channel, MAC.. Mitochondria and Oxidative Stress in Neurodegenerative Disorders. New York: New York Academy of Sciences.

Peixoto, P. M., Roy, T. J., Flores, M., & Campo, M. (2007, February 28). Dynamics of the ligand-gated channel of TIM22: The protein insertion complex in native mitochondrial inner membranes. 48th Annual Meeting of The Biophysical Society. Baltimore, MD: Biophysical Society.

Lue, J. K., Peixoto, P. M., Terracio, L., Sammuels, H. S., Wroble, B., Sible, J., Martinez-Caballero, S., & Kinnally, K. W. (2007, September 29). Mitochondrial apoptosis induces two types of bystander effects. Mitochondria and Oxidative Stress in Neurodegenerative Disorders. New York: New York Academy of Sciences.

Peixoto, P. M., Grana, F. O., Flores, M., Roy, T. J., & Campo, M. (2006, July 6). The native channel activity behind the mitochondrial inner membrane insertase. 8th European Biological Chemistry Conference. Aveiro, Portugal: Portuguese Society for Biological Chemistry.

Peixoto, P. M. (2006, September 8). Electrophysiological characterization of the mitochondrial protein import channels TIM23 and TIM22. 29th Meeting of the Spanish Society for Biochemistry and Molecular Biology. Elche, Spain: The Spanish Society for Biochemistry and Molecular Biology.

Peixoto, P. M., Martinez-Caballero, S., Kinnally, K. W., & Campo, M. (2004, February 28). The channel activity of the protein translocase TIM22 detected in the inner membranes of mitochondria.. 46th Annual Meeting of The Biophysical Society. Baltimore, MD: Biophysical Society.

Research Currently in Progess

Peixoto, P., Jeon, S., & Zapata, K.(n.d.). An optogenetic approach to study oxidative signaling in neurodegeneration. In Progress.

Hartke, R., Damri, K., Mirzalieva, O., Azem, A., Dunn, C., & Peixoto, P.(n.d.). Metabolic roles of the newly identified mitochondrial protein Mgr2. In Progress.

Peixoto, P., & Zapata, K.(n.d.). Oxidative signaling in cultured motor neurons. In Progress.

Latchman, N., & Peixoto, P.(n.d.). Study of alternative functions of the mitochondrial protein Bak.. In Progress.

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